Filgrastim, sold under the brand name neupogen among others, is a medication used to treat. Clinical safety and efficacy of filgrastim biosimilar 2 in japanese. The drug can be injected directly into the skin or into a vein. Nov 09, 2018 filgrastim zarxio is used to treat neutropenia, a lack of certain white blood cells caused by cancer, bone marrow transplant, receiving chemotherapy, or by other conditions. Filgrastim dosing during chemotherapy the recommended starting filgrastim dose for preventing infections during chemotherapy is based on body weight filgrastim 5 mcg per kg each day about 2. The recommended starting dosage of zarxio is 5 mcgkgday administered as a single daily injection by subcutaneous injection by short intravenous infusion 15 to 30 minutes or by continuous intravenous infusion.
Insert the needle into your skin in one quick motion at a 90degree straight up and down angle see figure 3. Please help improve this section by adding citations to reliable sources. By continuing to browse the site you are agreeing to our policy on the use of cookies. Patient package insert neupogen filgrastim 29 may 2002 page 7of 5. Other recombinant filgrastim products are poorly secreted into breast milk, and filgrastim is not orally absorbed by neonates. With filgrastim, its important to watch for potentially dangerous drug interactions and take blood tests regularly to measure neutrophil levels in your blood. A recombinant form of granulocyte colonystimulating factor, used as a drug to treat neutropenia especially as a result of chemotherapy, and in patients. It may also be used to increase white blood cells for gathering during leukapheresis.
Call your doctor right away if you have sudden or severe pain in your left upper stomach. Under object type, select adobe acrobat document and. Neupogen filgrastim injection, for subcutaneous or. Filgrastim is sometimes called gcsf, or granulocyte colony stimulating factor. Filgrastim is available in different dosage strength of 300 g 0. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for granix tbofilgrastim skip to. Highlights of prescribing information these highlights. Neulasta is contraindicated in patients with a history of serious allergic reactions to pegfilgrastim or filgrastim. Gcsf is produced in the body by the immune system and stimulates the formation of one type of white blood cell, the neutrophil. In addition, filgrastim is essential for bone marrow and peripheral blood stem cell. Click insert to insert the images into the word document.
Neutropenia may be a longstanding condition in which the body does not make enough neutrophils or it may be caused by drugs used to treat cancer. Filgrastim definition of filgrastim by the free dictionary. Get emergency medical help if you have signs of an allergic reaction. Filgrastim is a synthetic pharmaceutical analogue of naturally occurring granulocyte colonystimulating factorgcsf. Granulocytecolony stimulating factor gcsfinduced mechanical. Diphenhydramine hydrochloride injection usp is available in preservative free 1 ml singledose vials, trays of 25. There is published literature documenting transfer of filgrastim into human milk. Administer the first dose of tbofilgrastim no earlier than 24 hours following myelosuppressive chemotherapy.
The approved dosage and modality of fbs2 varies depending on the indication, and a different. Granulocyte colonystimulating factor filgrastim in. Dispose of that syringe in the punctureproof disposal container. Here are the steps to inserting a pdf file into a word document. Filgrastim is a manmade version of a certain natural substance made in your body. Package insert diphenhydramine hydrochloride injection, usp. If the syringe package is undamaged, open the package and remove the syringe. Precautions and warnings with filgrastim before starting a new medication, make sure you are aware of the drugs precautions and warnings. Projected place in therapy product licensed filgrastimsndz has been. Use your thumb whichever thumb is more comfortable to slowly push the plunger all the way down.
Pegfilgrastim information for patients and caregivers. Gcsf also mobilizes stem cells, prompting them to enter the. Filgrastim is a clear liquid that is injected under your skin or into a vein. Neupogen is indicated in adult and pediatric patients with cancer receiving. Nccn guidelines state that based on clinical trial data, pegfilgrastim should be administered the day after chemotherapy category 1 recommendation 4. Highlights of prescribing information neulasta safely and. Other considerations do not administer to patients with latex allergy. The easiest ways to insert a pdf into word, either as an image or in an editable format, online or offline. Jul 10, 2008 conversely, patients randomized to active daily filgrastim received a single pegfilgrastimmatched placebo injection in each cycle. Filgrastim zarxio side effects, dosage, interactions. Neulasta pegfilgrastim information for patients and. Product monograph prneupogen filgrastim sterile solution. Make sure you understand the package directions and feel comfortable with the injections. Downloading fda package insert for granix injection.
The number of days you receive filgrastim will be prescribed by your doctor. Filgrastim definition of filgrastim by medical dictionary. Neupogen is indicated to increase survival in patients acutely exposed to myelosuppressive doses of radiation see clinical studies 14. These highlights do not include all the information needed.
Remove from refrigerator 30 minutes before injection. In some cases, the body may make enough neutrophils but, as part of cancer treatment, the doctor may want to increase the number of certain. In rare instances, patients with congenital neutropenia have required doses of filgrastim greater than or equal to 100 mcgkgday. Patient package insert 29 may 2002 neupogen filgrastim. This patient package insert does not tell you everything about neulasta. Filgrastim may also be used for purposes not listed in this medication guide. Filgrastim can cause your spleen to become enlarged and it could rupture tear. Neupogen, granix, zarxio, nivestym filgrastim, tbo. Microsoft word 2010 includes native functionality that allows you to import, or insert, a pdf file into a word document.
Do not administer tbofilgrastim within 24 hours prior to chemotherapy see warnings and precautions 5. You should discuss any questions you have about treatment with neulasta with your doctor. However, this will only insert the text without the original formatting or graphics if any from the pdf file, so it wont look. If you will be giving yourself the shot, your doctor or nurse will teach you how to give the shot. Pegfilgrastim medical definition merriamwebster medical. Place your cursor by clicking on the area where you wish to insert the pdf document. Filgrastim neupogen is a manmade protein that is similar to the naturally occurring protein, granulocytecolony stimulating factor gcsf. However, no adverse effects in breastfeeding infants have been noted. If you are giving your own injection at home, use filgrastim exactly as directed by your doctor. Filgrastim is a synthetic copy of the bodys own growth factor to make more neutrophils. Neupogen is indicated for the mobilization of autologous hematopoietic progenitor cells into the peripheral blood for collection by leukapheresissee clinical studies 14. Conversely, patients randomized to active daily filgrastim received a single pegfilgrastimmatched placebo injection in each cycle. Neupogen filgrastim can lower your risk of infection during chemotherapy, but it can cause a significant amount of bone pain. If youre looking to insert the contents of your pdf file into an office file, as opposed to simply inserting the pdf as an attachment, then your best bet is to open that pdf with word 20 or 2016.
Data from interviews with neulasta treatmentexperienced oncology patients n227, pfs n150, neulasta onpro n77 conducted in november 2016. The effects of filgrastim on human milk production are unknown. It may be given into a vein by a doctor or other healthcare provider. A single dose of pegfilgrastim compared with daily.
Pegfilgrastim definition of pegfilgrastim by medical dictionary. Filgrastim injection products come as a solution liquid in vials and prefilled syringes to inject under the skin or into a vein. This was a prospective, open, phase iv clinical trial in patients receiving chemotherapy for histologically confirmed cancer, with an oral temperature of 38. Filgrastim, lenograstim, nartograstim, pegfilgrastim. Filgrastim granulocyte colonystimulating factor gcsf is used to stimulate the production of white blood cells, which prevents infection in patients whose white blood cell count has diminished because of the effects of anticancer drugs. Filgrastim is used to treat neutropenia, a condition in which the body makes too few neutrophils. Medicines containing the active ingredient filgrastim emc.
Pdf, or portable document format, files are commonly used for product specification sheets and user manuals. Filgrastim, sold under the brand name neupogen among others, is a medication used to treat low neutrophil count. Neupogen is produced by escherichia coli e coli bacteria into which has been inserted the human granulocyte colonystimulating factor gene. Filgrastimsndz zarxio national drug monograph september 2016. Jan 16, 2020 it is given as a shot into the fatty part of the skin. These highlights do not include all the information needed to. It stimulates the growth of a type of white blood cells called neutrophil granulocytes, or neutrophils. The transfer of filgrastim into human milk has been documented in published literature. In agreement, gcsf injection induced significant tnf.
Package insert diphenhydramine hydrochloride injection. This patient package insert provides information and instructions for people who will be receiving neulasta or their caregivers. Neupogen is a 175 amino acid protein manufactured by recombinant dna technology. Drug interactions between filgrastim and other drugs have not been fully evaluated. Pronunciation of filgrastim with 2 audio pronunciations, 6 translations and more for filgrastim. Comparing granulocyte colonystimulating factor filgrastim. Filgrastim medical definition merriamwebster medical. Package insert lists common adverse reactions from reference labeling. Compare prices, print coupons and get savings tips for filgrastim neupogen and other neutropenia drugs at cvs, walgreens, and other pharmacies. The first biosimilar product approved in the united states is filgrastimsndz zarxio, sandoznovartis, which was found to be similar to amgens neupogen. Find out what health conditions may be a health risk when taken with filgrastim injection.
Keeping the needle in the vial, turn the vial upside down. The following is the supplementary data related to this article. Generic and brand name of filgrastim the drug is available under generic name filgrastim and brand names filcad, imumax, neukine, neupogen, grafeel, emgrast, religrast, zarzio or zarxio and nufil the filgrastim is marketed in by cadila pharmaceuticals. Filgrastim, lenograstim, nartograstim, pegfilgrastim september, 2016. Microsoft word allows you to create a variety of documents for practically every aspect of your business. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for granix tbo filgrastim. Sep 30, 2014 filgrastim works in the bone marrow, where new blood cells are made. Projected place in therapy product licensed filgrastim sndz has been shown to be biosimilar the reference filgrastim in the u. Word will convert the pdf to editable text and you can then copy and paste that text into your office document. After the administration of filgrastim, the anc level and oral temperature were measured and documented every six hours. It is used to help your body make more white blood cells. White blood cells are important to help you fight off.
Neupogen filgrastim is a 175 amino acid human granulocyte colonystimulating factor gcsf manufactured by recombinant dna technology. Mar 15, 2020 filgrastim is used to treat neutropenia, a lack of certain white blood cells caused by cancer, bone marrow transplant, receiving chemotherapy, or by other conditions. Both pegfilgrastim and filgrastim were formulated as clear, colorless, aqueous solutions. Chronic daily administration is required to maintain clinical benefit. It is usually given once a day, but filgrastim injection products neupogen, nivestym, zarxio may be given twice a day when it is used to treat severe chronic neutropenia. Dosage adjustments in patients with severe chronic neutropenia. Read more i understand that some in australia are getting subsidized filgrastim neupogen, hopefully you wont need it but id be discussing with my specialist so you. Low neutrophil counts may occur with hivaids, following chemotherapy or radiation poisoning, or be of an unknown cause. Neupogen is produced in e coli the product is nonglycosylated and thus differs. The human gcsf gene was inserted into escherichia coli using recombinant dna technology to produce filgrastim, which has been approved for clinical use since 1991. Pegfilgrastim definition of pegfilgrastim by medical. Escherichia coli e coli bacteria into which has been inserted the human granulocyte colonystimulating factor gene. Webmd provides common contraindications for filgrastim injection.
A single dose of pegfilgrastim compared with daily filgrastim. Filgrastim is a human granulocyte colonystimulating factor gcsf produced by recombinant dna technology. Package insert availability each ml of diphenhydramine hydrochloride injection usp contains diphenhydramine hydrochloride 50 mg, sodium hydroxide andor hydrochloric acid to adjust ph and water for injection. Filgrastim works in the bone marrow, where new blood cells are made. Keep taking filgrastim injection as you have been told by your doctor or other health care provider, even if you feel well. Matched placebo vials were indistinguishable from those containing active agent. The recommended dose of tbofilgrastim is 5 mcgkg per day administered as a subcutaneous injection. It is given either by injection into a vein or under the skin. Filgrastim may be given subcutaneous the layer between the skin and muscle injection or infused into a vein intravenous, iv. The package insert for ribavirin recommends reducing the ribavirin dose at hemoglobin levels less than 10 gdl and permanently discontinuing the drug at levels less than 8. For more information, go to edit pdf content in word. If the package has been opened or damaged, do not use that syringe. Filgrastim was administered subcutaneously in a dose of 5 mcgkgday, 24 hours after administration of cytotoxic therapy, for up to two weeks or until the anc reaches 10,000 cellsmm 3.
Filgrastim zarxio is used to treat neutropenia, a lack of certain white blood cells caused by cancer, bone marrow transplant, receiving chemotherapy, or by other conditions. Learn more about the word filgrastim, its origin, alternative forms, and usage from wiktionary. Because of its relatively short circulating halflife, daily filgrastim injections are required to stimulate neutrophil recovery. Giving yourself an injection of filgrastim neupogen or. All patients in the study were asked to list one word adjectives or short phrases that best described how they felt after receiving chemotherapy. If you decide not to selfinject and dont have someone to do it for you, youll need to have your doctor or trained medical staff give you each dose of neupogen filgrastim.
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